The Nielsen Laboratory
We have two major research projects: 1. plant organelle DNA maintenance; 2. gene expression and proteomics analysis in halophytes.
Mitochondria are the powerhouses of eukaryotic cells and produce ATP for cellular processes. Chloroplasts are the site of photosynthesis. Both of these organelles contain DNA (mtDNA and ctDNA) that encodes only a few essential genes, while most proteins for mitochondrial and chloroplast function are encoded in the nucleus and must be imported into the organelles. We are interested in the mechanisms by which organelle DNA is replicated and maintained.
Our laboratory has been working for many years to study plant genes encoding mtDNA and ctDNA replication and recombination proteins and to determine their role in the maintenance of the organelle genomes during plant development. We are analyzing T-DNA insertion mutants